Published by Clinical Pain Advisor

In a prospective pilot study reported in the Journal of Nature and Science, researchers at the University of Michigan observed changes in several measures of pain in patients suspected of opioid-induced hyperalgesia (OIH) after transitioning from opioids to buprenorphine.

In the 2016 Centers for Disease Control and Prevention Guideline for Prescribing Opioids for Chronic Pain, the risk for OIH was noted as an area of concern in addition to the potential for opioid abuse and overdose. Previous findings by the investigators of the current study show that “patients on opioids with persistently high pain scores reported a phenotype consistent with having a more centralized pain state (fibromyalgia-like presentation), which suggests the potential presence” of OIH. Patients with suspected OIH and taking >100 mg oral morphine equivalents (OME) were found to have lower pressure pain tolerance than those taking <100 mg OME.

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