(Modic type 1 changes): a double-blind randomized clinical controlled trial of efficacy.
Albert HB, Sorensen JS, Christensen BS, Manniche C.



Modic type 1 changes/bone edema in the vertebrae are present in 6 % of the general population and 35-40 % of the low back pain population. It is strongly associated with low back pain. The aim was to test the efficacy of antibiotic treatment in patients with chronic low back pain (>6 months) and Modic type 1 changes (bone edema).